Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction

Authors

Jeffrey S. Mogil
Robert E. Sorge
Michael L. LaCroix-Fralish
Wendy Faith Sternberg, Haverford College

Document Type

Journal Article

Role

Author

Standard Number

1097-6256

Journal Title

Nature Neuroscience

Volume

14

Issue

12

First Page

1569

Last Page

U99

Publication Date

2011

Abstract

"This is a major publication, and my first in any of the Nature line of journals. It represents an extensive investigation involving four labs throughout the US and Canada (including mine!). It illustrates sex differences in neurochemical mediation of stress induced analgesia in humans and animals, and shows similarity in mechanism across species." --author-supplied description

Repository Citation

Mogil JS, Sorge RE, LaCroix-Fralish ML, Smith SB, Fortin A, Sotocinal SG, Ritchie J, Austin JS, Schorscher-Petcu A, Melmed K, Bittong RA, Mokris JB, Neubert JK, Campbell CM, Edwards RR, Campbell JN, Crawley JN, Lariviere WR, Wallace MR, Sternberg WF, Balaban CD, Belfer I, Fillingim RB (2011). Pain sensitivity and vasopressin analgesia in mice and humans is mediated by a gene-sex-environment interaction involving the AVPR1A gene and acute stress. Nature Neuroscience, 14(12), 1569-1573.