The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C(-) monocytes
This paper, in one of the best immunology journals in the world (really), was the result of a wonderful collaboration between three labs - ours at Haverford, Geissman's in London, and Lynn Hedrick's it the La Jolla Allergy and Immunology Institute in California. Lynn spearheaded the study and contacted me about the possibility of using our new reporter mice. It turned out that we (truly Harper Hubbeling '11, a Beckman Scholar in my laboratory) had already been doing some of the experiments she was proposing. We decided to incorporate our data with hers - and she boldly sent the work to Nature Immunology. After some revisions, they accepted it - a very, very exciting time and publication for us - and for Harper. The paper shows that the gene Nur77 (which regulate cell fates in way we are still working to understand) is critical for the development and function of a special population of white blood cells (patrolling monocytes). Rather than enhance inflammation, these cells quell it and are likely to play an important role in maintaining an organisms' health between infections. --author-supplied description
Hanna, R. N., Carlin, L., Hubbeling, H. G ., Nac kiewicz, D., Green, A. M. Punt, J.A ., Geissmann, F., and Hedrick, C.C. (2011) The tran scription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C( - ) monocytes. Nature Immunology 12:778 - 785.