Targeting extracellular collagen assembly to enhance functional recovery in composite neuromuscular trauma

Document Type

Journal Article

Role

Author

Published In

Connective Tissue Research

Publication Date

6-27-2026

Abstract

Composite neuromuscular injuries involving damage to peripheral nerves and skeletal muscles result in poor functional recovery due to excessive scarring. Current therapies lack specificity or carry significant side effects. We investigated the efficacy of a recombinant anti-collagen antibody (ACA) designed to inhibit extracellular collagen fibril formation, thereby reducing scar formation without disrupting intracellular reparative pathways.

Keywords

composite neuromuscular injury, therapeutic antibody, fibrosis, collagen fibrils, peripheral nerve

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