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Submissions from 2017

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Twists And Turns In Protein Assembly, Robert Fairman

Genetics: Genes, genomes, and evolution, Kate Heston, Rachel Hoang, Philip Meneely, and Iruka Okeke

Submissions from 2016

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Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO, Hande Boyanci, Tayyab Shah, Amanda Hurley, and Robert Fairman

Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection, Robert Fairman, Lynn Richmond '13, Jay Garcia '16, and Kathleen Ulrich '14

Weak tradeoff between xylem safety and xylem-specific hydraulic efficiency across the world's woody plant species, Sean M. Gleason, Mark Westoby, Steven Jansen, and Radika Bhaskar

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A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi, E. L. Harvey, R. W. Deering, D. C. Rowley, and Kristen E. Whalen

Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2, Ellen J. Hoffman, Katherine J. Turner, Joseph M. Fernandez, and Roshan A. Jain

Probing the selectivity of beta-hydroxylation reactions in non-ribosomal peptide synthesis using analytical ultracentrifugation, Bashkim Kokona, Emily S. Winesett '16, A. Nikolai von Krusenstiern '15, Robert Fairman, and Louise K. Charkoudian

Was atmospheric CO2 capped at 1000 ppm over the past 300 million years?, Jennifer C. McElwain, Isabel P. Montañez, Joseph D. White, and Jonathan P. Wilson

Pick Your Poisson: An Educational Primer for Luria and Delbruck's Classic Paper, Philip Meneely

Climate, p(CO2) and terrestrial carbon cycle linkages during late Palaeozoic glacial-interglacial cycles, Isabel P. Montanez, Jennifer C. McElwain, Christopher J. Poulsen, and Jonathan P. Wilson

Diarrhoeagenic Escherichia coli in mother-child Pairs in Ile-Ife, South Western Nigeria, Iruka N. Okeke, Babatunde W. Odetoyin, Jennifer Hofmann, and Aaron O. Aboderin

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Biosynthesis of coral settlement cue tertrabromopyrrole in marine bacteria by a uniquely adapted brominase-thiosterase enzyme pair., Kristen E. Whalen, Abrahim El Gamal, Vinayak Agarwal, and Stefan Diethelm

Hydraulics of Psilophyton and evolutionary trends in plant water transport after terrestrialization, Jonathan P. Wilson

Submissions from 2015

Effect of Helix Length on the Stability of the Lac Repressor Antiparallel Coiled Coil, Wheaton Little, James P. Robblee, Caroline L. Dahlberg, Bashkim Kokona, and Robert Fairman

Enhancement of antibiotic activity against multidrug resistant bacteria by efflux pump inhibitor, 3,4‐dibromo‐2,5‐dione, isolated from a Pseudoalteromonas sp, Kristen E. Whalen, K. L. Poulson, R. W. Deering, and D. C. Rowley

A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning, Marc A. Wolman, Roshan A. Jain, and Kurt C. Marsden

Submissions from 2014

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Enteroaggregative Escherichia coli Have Evolved Independently as Distinct Complexes within the E-coli Population with Varying Ability to Cause Disease, Marie Anne Chattaway, Claire Jenkins, Dunstan Rajendram, and Iruka N. Okeke

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Comparative Genomics of 274 Vibrio Cholerae Genomes Reveals Mobile Functions Structuring Three Niche Dimensions, Bas E. Dutilh, Cristiane C. Thompson, Ana C P Vicente, and Iruka N. Okeke

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Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons, Roshan A. Jain

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Effect of Helical Flanking Sequences on the Morphology of Polyglutamine-Containing Fibrils, Bashkim Kokona, Karl A. Johnson, and Robert Fairman

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Role of the Coiled-Coil Structural Motif in Polyglutamine Aggregation, Bashkim Kokona, Zachary P. Rosenthal, and Robert Fairman

Genetic Analysis: Genes, Genomes, and Networks in Eukaryotes, 2nd edition, Philip Meneely

Diagnostic Schemes for Reducing Epidemic Size of African Viral Hemorrhagic Fever Outbreaks, Iruka N. Okeke and Robert S. Manning

Confronting Contagion: Our Evolving Understanding of Disease, Melvin Santer

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Dissemination of the Transmissible Quinolone-Resistance Gene qnrS1 by IncX Plasmids in Nigeria, Eric T. Sumrall '13, Elizabeth B. Gallo '12, Aaron Aboderin Oladipo, Adebayo Lamikanra, and Iruka N. Okeke

Testing the Role of Charge and Structure on the Stability of Peptide-Porphyrin Complexes, James C. Taggart, Elizabeth Z. Welch, Mary F. Mulqueen, Vincent B. Dioguardi, and Robert Fairman

Submissions from 2013

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The Carbon Isotope Organic Geochemistry of Early Ordovician Rocks from the Annascaul Formation, County Kerry, A. H. Jahren, Brian A. Schubert, Leszek Marynowski, and Jonathan P. Wilson

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Using a Peptide System to test the Coiled-Coil Model of Polyglutamine Aggregation, Bashkim Kokona, Karl A. Johnson, and Robert Fairman

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Flagellar Waveform Dynamics of Freely Swimming Algal Cells, H. Kurtuldu, D. Tam, A. E. Hosoi, and Karl A. Johnson

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Cholera Outbreaks in Nigeria are Associated with Multidrug Resistant Atypical El Tor and non-O1/non-O139 Vibrio cholerae., M. A. Marin, C. C. Thompson, F. S. Freitas, E. L. Fonseca, and Iruka N. Okeke

SMG-ly Knocking out Gene Expression in Specific Cells; An Educational Primer, Philip M. Meneely and J. C. Bloom

Kuby Immunology, Judith A. Owen, Jennifer Punt, Sharon A. Stranford, and Patricia P. Jones

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Exploring the Interactions between a Coiled-Coil Model Peptide System and Metallated Porphyrins towards the Design of Photoelectronically active Biomaterials, James C. Taggart '13, Elizabeth Z. Welch, Bashkim Kokona, and Robert Fairman

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Modeling 400 million years of plant hydraulics, Jonathan P. Wilson

Submissions from 2012

Prolonged febrile illness due to CTX-M-15 extended spectrum beta-lactamase-producing Klebsiella pneumoniae infection in Nigeria, A. O. Aboderin, O. Adefehinti, B. W. Odetoyin, and Iruka N. Okeke

NF-Y is necessary for hematopoietic stem cell proliferation and survival, Gerd Bungartz, Hannah Land, David T. Scadden, and Stephen G. Emerson

Effect of charged residue side chain length on intrahelical glutamate-lysine ion pairing interactions, Richard P. Cheng, Wei-Ren Wang, Prashant Girinath, and Robert Fairman

Evolutionary Voyage of Angiosperm Vessel Structure-Function and its Significance for Early Angiosperm Success, T. S. Field and Jonathan P. Wilson

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis, Richard N. Hanna, Iftach Shaked, Harper G. Hubbeling, and Jennifer Punt

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Regional Dissemination of a Trimethoprim-Resistance Gene Cassette via a Successful Transposable Element, Amy S. Labar '10, Jennifer S. Millman '09, E. Ruebrush, and Iruka N. Okeke

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Netrin/DCC signaling guides olfactory sensory axons to their correct location in the olfactory bulb, Vanisha Lakhina, Christina L. Marcaccio, Xin Shao, and Roshan A. Jain

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses, Justine Melo

Crossover distribution and frequency are regulated by him-5 in Caenorhabditis elegans, Philip M. Meneely, Olivia L. McGovern, Frazer I. Heinis, and Judith L. Yanowitz

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Africa in the time of cholera: a history of pandemics from 1817 to the present [book review], Iruka N. Okeke

Measures to ensure better use of antibiotics, Iruka N. Okeke

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Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli., Kristen E. Whalen, A Reitzel, and A. Hamdoun

Deep-Water Incised Valley Deposits at the Ediacaran-Cambrian Boundary in Southern Namibia Contain Abundant Treptichnus Pedum, Jonathan P. Wilson, J. P. Grotzinger, Wooward W. Fischer, and K. P. Hand

Submissions from 2011

Evolution of folded gastrulation: A comparison between Drosophila melanogaster and Drosophila pseudoobscura, Frederick Arnold '12, Kimberly Dao '09, Jill Geratowski '11, and Rachel E. Hoang

Enteroaggregative E. coli O104 from an outbreak of HUS in Germany 2011, could it happen again?, Marie Anne Chattaway, Tim Dallman, Iruka N. Okeke, and John Wain

GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+thymocytes to polarize their MTOC in response to TCR stimulation, Nicole R. Cunningham, Emily M. Hinchcliff '08, Vassily I. Kutyavin '11, and Jennifer Punt

The Vaccinia Virus A56 protein: A Multifunctional Transmembrane Glycoprotein that Anchors Two Secreted Viral Proteins, Brian DeHaven

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Measuring oscillatory velocity fields due to swimming algae, J. S. Guasto, Karl A. Johnson, and Jerry P. Gollub

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C(-) monocytes, Richard N. Hanna, Leo M. Carlin, Harper G. Hubbeling, and Jennifer Punt

A Phase 1 Dose Escalation Study of Infusion of Ex Vivo CD3/CD28 Costimulated Umbilical Cord Blood-Derived T Cells in Adults Undergoing Transplanation for Advanced Hematologic Malignancies , E. Hexner, S. M. Luger, J. K. Mangan, and Stephen G. Emerson

How the Hox Gene Ubx Specifies Two Different Segment Identities, Rachel E. Hoang

Hox Genes And The Evolution Of The Vertebrate Body Plan, Rachel E. Hoang

Interactions Between Vertebrate Hox Genes, Rachel E. Hoang

The Dynamics and Mechanics of Apical Constriction, Rachel E. Hoang

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Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance, Roshan A. Jain, Marc A. Wolman, and Lauren A. Schmidt

Enhancement of biomixing by swimming algal cells in two-dimensional films, H. Kurtuldu, J. S. Guasto, Karl A. Johnson, and Jerry P. Gollub

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Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use, Adebayo Lamikanra, Jennifer L. Crowe, Rebeccah S. Lijek '07, and Iruka N. Okeke

A novel Nr4a1(GFP) Reporter System Reveals that Nr4a1 Expression Identifies Long-Term Hematopoietic Stem Cells, Ruben Land '12, Trevor Barlowe '13, Shwetha Manjunath '11, Stephen G. Emerson, and Jennifer Punt

The Heat-Resistant Agglutinin Family Includes a Novel Adhesin from Enteroaggregative Escherichia coli Strain 60A, Justin Mancini '09, Brooke Weckselblatt, Yoonjie K. Chung '10, and Iruka N. Okeke

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T cell receptor signal strength in Treg and iNKT cell development as revealed by a novel fluorescent reporter mouse, Amy E. Moran, Keli L. Holzapfel, Nicole R. Cunningham, and Jennifer Punt

T-Cell receptor signal strength in T-reg and iNKT cell development demonstrated by a novel flourescent reporter mouse, Amy E. Moran, Keli L. Holzapfel, Yan Xang, and Jennifer Punt

Non-prescription antimicrobial use worldwide: a systematic review, D. J. Morgan, Iruka N. Okeke, R. Laxminarayan, and E. N. Perencevich

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Quinolone resistance in Escherichia coli from Accra, Ghana, Sreela S. Namboodiri '08, Japheth A. Opintan, Rebeccah S. Lijek '07, and Iruka N. Okeke

Biomedical Loopholes, Distrusted State and the Politics of HIV/AIDS 'Cure' in Nigeria, E. B. Obadare and Iruka N. Okeke

Divining without seeds : the case for strengthening laboratory medicine in Africa, Iruka N. Okeke

Ensuring Global Access to Quality Medicines: Role of the US Pharmacopeia, Iruka N. Okeke, Matthew L. Heyman, and Roger L. Williams

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IS3 Profiling Identifies the Enterohaemorrhagic Escherichia Coli O-island 62 in a Distinct Enteroaggregative E. Coli Lineage, Iruka N. Okeke, Louissa R. MacFarlane-Smith, Jonathan N. Fletcher, and Anna M. Snelling

Diagnostics as Essential Tools for Antimicrobial Resistance Containment, Iruka N. Okeke, Rosanna W. Peeling, Herman Goossens, and Raymond Auckenthaler

Characterization of Mesoscale Coiled-Coil Peptide-Porphyrin Complexes, Brian J. Pepe-Mooney '10, Bashkim Kokona, and Robert Fairman

IFNs Upregulate Sca-1 and Block Proliferation in Murine Hematopoietic Stem and Progenitor Cells, K. Shank, Y. Shin, C. Wills, and Jennifer Punt

A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin, Kristina S. Sinsimer, Roshan A. Jain, Seema Chatterjee, and Elizabeth R. Gavis

Vibrio cholerae O1 lineages driving cholera outbreaks during seventh cholera pandemic in Ghana, Cristiane C. Thompson, F. S. Freitas, Michel A. Marin, and Iruka N. Okeke

Thermodynamic Analysis of Self-Assembly in Coiled-Coil Biomaterials, Betty P. Tsang '07, Heidi S. Bretscher '09, Bashkim Kokona, and Robert Fairman

Drug-resistant Bacteria and Childhood Diarrhea in Africa, Faith Wallace-Gadsden and Iruka N. Okeke

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Geochemical Support for a Climbing Habit within the Paleozoic Seed Fern Genus Medullosa, Jonathan P. Wilson and Woodward W. Fischer

Hydraulics of Asteroxylon mackei, an early Devonian vascular plant, and the early evolution of water transport tissue in terrestrial plants, Jonathan P. Wilson and Woodward W. Fischer

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Chemical modulation of memory formation in larval zebrafish, Marc A. Wolman, Roshan A. Jain, Laura Liss, and Michael Granato

Notch signaling is a critical regulator of allogeneic CD4(+) T-cell responses mediating graft-versus-host disease, Yi Zhang, Ashley R. Sandy, Jina Wang, and Stephen G. Emerson

Submissions from 2010

Positional Effects on Helical Ala-Based Peptides, Richard P. Cheng, Prashant Girinath, Yuta Suzuki, and Robert Fairman

Molecular Biology: Principles of Genome Function, Nancy L. Craig, Orna Cohen-Fix, Rachel Green, and Philip M. Meneely

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Poxvirus Complement Control Proteins are Expressed on the Cell Surface through an Intermolecular Disulfide Bridge with the Viral A56 Protein, Brian DeHaven

TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells, Alevtina D. Domashenko, Gwenn Danet-Desnoyers, Alissa Aron '11, and Stephen G. Emerson

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Pharmacologic eigenvalues: beating the rap on bone marrow failure, Stephen G. Emerson and R. W. Garrett

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The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection, N. M. Girgis and Brian DeHaven

Xenopus sonic hedgehog Guides Retinal Axons Along the Optic Tract, Laura Gordon, Matthew Mansh, Helen Kinsman, and Andrea R. Morris

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Oscillatory Flows Induced by Microorganisms Swimming in Two Dimensions, J. S. Guasto, Karl A. Johnson, and Jerry P. Gollub

Journal Club, Rachel E. Hoang

A Pathoadaptive Deletion in an Enteroaggregative Escherichia coli Outbreak Strain Enhances Virulence in a Caenorhabditis elegans Model, Jennifer Hwang '09, Lisa M. Mattei, Laura G. Van Arendonk '10, Philip M. Meneely, and Iruka N. Okeke

The Effects of Mild Post-Stroke Exercise on Reactive Neurogenesis and Recovery of Somatosensation in Aged Rats, J. L. Leasure and Michael Grider

Genomes and Genetic Variation, Philip M. Meneely

Poverty and Root Causes of Antimicrobial Resistance, Iruka N. Okeke

Antimicrobial resistance and use in Africa, Iruka N. Okeke and K. K. Ojo

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Multi-Locus Sequence Typing of Enteroaggregative Escherichia coli Isolates from Nigerian Children Uncovers Multiple Lineages, Iruka N. Okeke, Faith Wallace-Gadsden, Hannah R. Simons '04, Nicholas Matthews, Amy S. Labar '10, and Jennifer Hwang '09

Carriage of diarrhoeagenic Escherichia coli by older children and adults in Accra, Ghana, Japheth A. Opintan, Rima A. Bishar, Mercy J. Newman, and Iruka N. Okeke

Understanding the functions of Cephalic hedgehog during Xenopus laevis neural development, L. Pineda-Salgado and Andrea R. Morris