Submissions from 2000

Rational modification of protein stability by the mutation of charged surface residues, S. Spector, M. Wang, S. A. Carp, and Robert Fairman

The Hematopoietic Microenvironment: Osteoblasts and the Hematopoietic Microenvironment, R. S. Taichman, M. J. Reilly, and Stephen G. Emerson

Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains, H. van der Keyl, Ziad F. Gellad '97, and Judith A. Owen

Submissions from 1999

Analysis of transglutaminase-catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease, B. J. Balin, Ariel G. Loewy, and D. M. Appelt

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment, A. Bhandoola, R. Cibotti, Jennifer Punt, and L. Granger

Collateral methotrexate resistance in cisplatin-selected murine leukemia cells, A. Bhushan, M. P. Hacker, and Thomas R. Tritton

Assessing apoptosis of developing T cells by flow cytometry, C. Bishop, A. Jost, E. Crane, and Jennifer Punt

Defining the core structure of the alpha-lactalbumin molten globule state., S. J. Demarest, J. A. Boice, Robert Fairman, and D. P. Raleigh

Clinical Applications of Hemtopoietic Stem Cell Culture and Expansion, Stephen G. Emerson and P. Conrad

Molecular weights of CTLA-4 and CD80 by sedimentation equilibrium ultracentrifugation, Robert Fairman, W. Fenderson, M. E. Hail, and Y. Wu


Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4+CD8+ thymocytes, Bruce D. Freedman, Qing-Hua Liu, Selin Somersan '99, and Jennifer Punt

Socioeconomic and behavioral factors leading to acquired bacterial resistance to antibiotics in developing countries, Iruka N. Okeke, A. Lamikanra, and R. Edelman

Antimicrobial spectrum of Alchornea cordifolia leaf extract, Iruka N. Okeke, O. Ogundaini, F. O. Ogungbamila, and A. Lamikanra

Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells, Warren Shlomchik, M. S. Couzens, C. B. Tang, and Stephen G. Emerson

Screening for genital chlamydial infection: the agenda for general practice., T. Stokes, Melvin Santer, and J. Mears

The Role of Osteoblasts in Hematopoiesis, R. S. Taichman and Stephen G. Emerson

Expression of the Bcl-2 family member A1 is developmentally regulated in T cells, M. M. Tomayko, J. Bolcavage, Jennifer Punt, and D. Allman

Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis, C. L. Zanella, C. R. Timblin, A. Cummins, and Thomas R. Tritton

Submissions from 1998

Gene Therapy for Leukemia and Lymphoma, S. Adams, Warren Shlomchik, and Stephen G. Emerson

Drug resistance results in alterations in expression of immune recognition molecules and failure to express Fas (CD95), A. Bhushan, J. L. Kupperman, J. E. Stone, and Thomas R. Tritton

Hematopoietic Expansion of Umbilical Cord Blood Cells: In Vitro and In Vivo Models, P. Conrad and Stephen G. Emerson

Lymphoid hyperplasia, autoimmunity, and intestinal intraepithelial colitis, in germ free gnotobiotic IL-2-deficient mice, N. V. Contractor, H. Bassiri, T. Reya, and Stephen G. Emerson

Altered functional responsiveness of thymocyte subsets from CD3d-deficient mice to TCR-CD3 engagement, V. P. Dave, R. Keefe, M. A. Berger, and Jennifer Punt

Peptide models of local and long-range interactions in the molten globule state of human alpha-lactalbumin, S. J. Demarest, Robert Fairman, and D. P. Raleigh

Hematopoiesis: The Development of Blood Cells, Stephen G. Emerson

Biochemical characterization of WrbA, founding member of a new family of multimeric flavodoxin-like proteins, R. Grandori, P. Khalifah, J. A. Boice, and Robert Fairman

Axonemal microtubules of the Chlamydomonas flagellum differ in tubulin isoform content, Karl A. Johnson

Structure and stability of the N-terminal domain of the ribosomal protein L9: Evidence for rapid two-state folding, B. Kuhlman, J. A. Boice, Robert Fairman, and D. P. Raleigh

Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution, C. L. Mackall, Jennifer Punt, P. Morgan, and A. G. Farr

The pyrophosphate-dependent phosphofructokinase of the protist, Trichomonas vaginalis, and the evolutionary relationships of protist phospho-fructokinases, E. Mertens, U. Ladror, J. Lee, and Andrea R. Morris

Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p, K. L. Nicholson, M. Munson, R. B. Miller, and Robert Fairman

Abnormal myelocytic cell development in IL-2-deficient mice: Evidence for the involvement of IL-2 in myelopoiesis, T. Reya, M. Couzens, Stephen G. Emerson, and S. Carding

Sex-restricted non-Mendelian Inheritance of Mouse Chromosome 11 in the Offspring of Crosses Between C57BL/6J and (C57BL/6J x DBA/2J)F1 Mice, J. Shendure and Justine Melo

Cooperative folding of a protein mini domain: the peripheral subunit-binding domain of the pyruvate dehydrogenase multienzyme complex., S. Spector, B. Kuhlman, Robert Fairman, and E. Wong

The role of osteoblasts in the hematopoietic microenvironment, R. S. Taichman and Stephen G. Emerson

Improved Efficiency of Liposome-mediated Transfection by Centrifugation, R. S. Verma, Warren S. Shlomchik, D. Giannola, and Stephen G. Emerson

Modulation of methotrexate resistance by genistein in murine leukemia L1210 cells, Y. Xuan, M. P. Hacker, Thomas R. Tritton, and A. Bhushan

Submissions from 1997

Spectroscopic properties of Escherichia coli UDP-N-acetylenolpyruvylglucosamine reductase, M. J. Axley, Robert Fairman, J. Yanchunas, and J. J. Villafranca

Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals, R. Cibotti, Jennifer Punt, K. S. Dash, and S. O. Sharrow

Approach to the Patient with Leukocytosis, Stephen G. Emerson

Cytokines in Ex-Vivo Stimulation of Blood Progenitor Cells, Stephen G. Emerson

Heteronuclear (1H, 13C, 15N) NMR assignments and secondary structure of the basic region-helix-loop-helix domain of E47, Robert Fairman, R. K. Beran-Steed, and T. M. Handel

Calcium binding peptides from alpha-lactalbumin: implications for protein folding and stability, B. Kuhlman, J. A. Boice, W. J. Wu, and Robert Fairman

Exceptionally stable helix from the ribosomal protein L9: implications for protein folding and stability, B. Kuhlman, H. Y. Yang, J. A. Boice, and Robert Fairman

Synthesis and use of a substrate for the detection of isopeptidase activity, Ariel G. Loewy, J. K. Blodgett, and Francis Rose Blase

Chromosomal signal for sex determination in Caenorhabditis elegans, Philip M. Meneely

A study of the effect of the urban/rural divide on the incidence of antibiotic resistance in Escherichia coli, Iruka N. Okeke and A. Lamikanra


T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus, Jennifer Punt, Wendy Havran, Ryo Abe, and Apurva Sarin

Protein designed by binary patterning of polar and nonpolar amino acids displays native-like properties, Sushmita Roy, Gayathri Ratnaswamy, Judith A. Boice, and Robert Fairman

Screening for genital chlamydial infection in women in general practice. Psychological effects of such screening are important, Melvin Santer

Infection and replication of human cytomegalovirus in bone marrow stromal cells: Effects on the production of IL-6, MIP-1alpha, and TGF-beta1, R. S. Taichman, M. R. Nassiri, M. J. Reilly, and Stephen G. Emerson

Human osteosarcomas inhibit hematopoietic colony formation: Partial reversal by antibody to transforming growth factor-beta 1, R. S. Taichman, M. J. Reilly, and Stephen G. Emerson

CD34+ bone marrow cells induce the expression and secretion of interleukin 6 (IL-6) by normal human osteoblasts, R. S. Taichman, M. J. Reilly, R. S. Verma, and Stephen G. Emerson

Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of ""ER-resident"" molecular chaperones, D. L. Wiest, A. Bhandoola, Jennifer Punt, and G. Kreibich

Developmentally regulated expression of peanut agglutinin (PNA)-specific glycans on murine thymocytes, W. Wu, Jennifer Punt, L. Granger, and S. O. Sharrow

Submissions from 1996

Relationships between bilayer structure and phospholipase A2 activity: interactions among temperature, diacylglycerol, lysolecithin, palmitic acid, and dipalmitoylphosphatidylcholine, J. D. Bell, M. Burnside, Judith A. Owen, and M. L. Royall

Correlation of altered tyrosine phosphorylation with methotrexate resistance in a cisplatin-resistant subline of L1210 cells, A. Bhushan, D. Wroblewski, Y. Xuan, and Thomas R. Tritton

Structural characterization of the tumor suppressor p16, an ankyrin-like repeat protein, J. A. Boice and Robert Fairman

Thermodynamic analysis of a designed three-stranded coiled coil, Judith A. Boice, G. R. Dieckmann, W. F. DeGrado, and Robert Fairman

Tamoxifen induces TGF-beta 1 activity and apoptosis of human MCF-7 breast cancer cells in vitro, H. Chen, Thomas R. Tritton, N. Kenny, and M. Absher

Ex-Vivo Expansion of Hematopoietic Precursors, Progenitors, and Stem Cells: The Next Generation of Cellular Therapeutics, Stephen G. Emerson

The Potential for Clinical Ex Vivo Hematopoiesis, Stephen G. Emerson

Design of heterotetrameric coiled coils: evidence for increased stabilization by Glu(-)-Lys(+) ion pair interactions, Robert Fairman, H. G. Chao, T. B. Lavoie, and J. J. Villafranca

Diversification of arthropod Hox genes as a paradigm for the evolution of gene functions, Rachel E. Hoang

Structural studies of Escherichia coli UDP-N-acetylmuramate: L-alanine ligase, H. Jin, J. J. Emanuele Jr., Robert Fairman, and J. G. Robertson

DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode Caenorgabditis elegans, J. D. Lieb, E. E. Capowski, Philip M. Meneely, and B. J. Meyer

Primary structure of a cytosolic malate dehydrogenase of the amitochondriate eukaryote, Trichomonas vaginalis, A. Markos, Andrea R. Morris, C. Rozario, and M. Muller

Identification of Sex-specific Quantitative Trait Loci Controlling Alcohol Preference in C57BL/6 mice, Justine Melo

Comparison of benzimidazole nucleosides and ganciclovir on the in vitro proliferation and colony formation of human bone marrow progenitor cells, M. R. Nassiri, Stephen G. Emerson, L. B. Townsend, and J. C. Drach

Successful in vitro antigen-dependent activation of 24-hour-old peripheral blood lymphocytes, Judith A. Owen, K. Muirhead, C. Jensen, and Z. L. Jonak


Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis, Jennifer Punt, Harumi Suzuki, Larry G. Granger, and Susan O. Sharrow

The Immune Response to Leukemias. Acta Haematologica, Warren Shlomchik and Stephen G. Emerson

Human MG-63 and SaOS-2 osteosarcoma cell lines produce G-CSF and GM-CSF: Identification and partial characterization of cell-associated isoforms, R. S. Taichman and Stephen G. Emerson

Human osteoblasts support human hematopoietic progenitor cells in long term in vitro bone marrow cultures, R. S. Taichman, M. J. Reilly, and Stephen G. Emerson

Gene family use and somatic mutation in primary and secondary fluorescein-specific IgM antibody responses, H. van der Keyl, C. Hsu, A. Tolat, and Judith A. Owen

Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline, D. H. Wroblewski, A. Bhushan, Y. Xuan, and Thomas R. Tritton


Identification of CD8 as a peanut agglutinin (PNA) receptor molecule on immature thymocytes, Wenyu Wu, Patricia H. Harley, Jennifer Punt, and Susan O. Sharrow

Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor, C. L. Zanella, J. Posada, Thomas R. Tritton, and B. T. Mossman

Submissions from 1995

The evolving role of Hox genes in arthropods, Michael Akam, Michelis Averof, Rachel E. Hoang, and Jaime Castelli-Gair

Dax, a locust Hox gene related to fushi-tarazu but showing no pair-rule expression, Michael Akam, Iain Dawson, Rachel E. Hoang, and Jaime Castelli-Gair

Design of two-stranded and three-stranded coiled-coil peptides, S. Betz, Robert Fairman, K. O'Neil, and J. Lear

Molecular cloning of the ETK-2 gene reveals alternative exon usage in the extracellular receptor domain, L. Biesecker, D. Giannola, and Stephen G. Emerson

Identification of a molecular chaperone in the eukaryotic flagellum and its localization to the site of microtubule assembly, M. A. Bloch and Karl A. Johnson

IL-1 alpha upregulates TNF alpha receptors expressed by a clonally derived bone marrow stromal cell strain: Implications for cytokine redundancy and synergy, J. Caldwell and Stephen G. Emerson

Retroviral infection of primitive hematopoietic cells in continuous perfusion culture, P. G. Eipers, J. C. Krause, B. O. Palsson, and Stephen G. Emerson

In Vitro Expansion of Hematopoietic Cells for Clinical Application, Stephen G. Emerson, B. O. Palsson, M. F. Clarke, and S. M. Silver

Characterization of a new four-chain coiled-coil: influence of chain length on stability, Robert Fairman, H. G. Chao, L. Mueller, and T. B. Lavoie

Identification of Kv1.1 expression by murine CD4-CD8- thymocytes. A role for voltage-dependent K+ channels in murine thymocyte development, B. D. Freedman, B. K. Fleischmann, Jennifer Punt, and G. Gaulton

DNA-binding domain of the hexameric arginine repressor, R. Grandori, T. A. Lavoie, M. Pflumm, and Robert Fairman

Fine specificity analysis indicates that the primary and secondary fluorescein-specific cytotoxic T cell receptor repertoires are indistinguishable, E. A. Hughes, G. Kinnel, C. Wickerham, and Judith A. Owen

Immunoelectron microscopy, Karl A. Johnson

Keeping the beat: form meets function in the Chlamydomonas flagellum, Karl A. Johnson

New motilities and motors in the flagella of Chlamydomonas, Karl A. Johnson


Early molecular events induced by TCR signaling in immature CD4+ CD8+ thymocytes, Kelly P. Kearse, Yousuke Takahama, Jennifer Punt, and Susan O. Sharrow

Bacterial capsules: a simple method for demonstration under the light microscope, Iruka N. Okeke and A. Lamikanra

Quality and bioavailability of tetracycline capsules in a Nigerian semi-urban community, Iruka N. Okeke and A. Lamikanra

T cell development, Jennifer Punt and A. Singer

Ribosomal RNA: An Historical Perspective, Melvin Santer

A mutation at the universally conserved position 529 in Escherichia coli 16S rRNA creates a functional but highly error prone ribosome., U. V. Santer, Julie Cekleniak '93, Sukesh K. Kansil '94, and Melvin Santer

Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells, A. R. Sepulveda, G. M. Habib, A. Damjanov, and Slavica Smit Matacic